PROJECTS:
Hindbrain patterning
Evo-devo
Pancreas development

PROJECTS: Pancreas development

Mary Kinkel - Research Associate (Assistant Professor), Department of Organismal Biology and Anatomy
Gokhan Dalgin - JDRF Postdoctoral Fellow, Department of Organismal Biology and Anatomy
Stefani Eames - Graduate student, Committee on Molecular Metabolism and Nutrition
Ranjani Logaraj - Undergraduate Student, Department of Organismal Biology and Anatomy
Crystal Love - Graduate student, Committee on Developmental Biology

Gokhan Dalgin   

Recent work in the Prince lab has shown that mesoderm-derived retinoic acid (RA) signals are received by RA receptors in the endoderm to specify the pancreas (Stafford et al 2006). My project is focused on identifying the
downstream targets of RA signaling that function in early pancreas development. Specifically, we have utilized microarray analysis to identify the downstream targets of RA signaling in endoderm by using Tg:Sox17-GFP fish.
Our analysis identified several Hox genes as targets of RA signaling. Initial analysis of endocrine pancreas development suggested that Hox genes control the specification of endocrine pancreas development. I am now focusing on how the Hox genes work together or in parallel with other known transcription factors to regulate patterning of the endocrine pancreas.

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