PROJECTS:
Hindbrain patterning
Evo-devo
Pancreas development

PROJECTS: Evo-Devo

Liz Sefton - Technician

We are interested in how different vertebrate body plans have evolved. Hox patterning genes play fundamental and broadly conserved patterning roles in all multicelled organisms. We have therefore been particularly interested in how Hox genes, and their clustered organization, have evolved within the vertebrates. In particular, we have explored how Hox genes important for hindbrain and pharyngeal patterning have evolved following a whole-genome duplication event in the ray-finned fish lineage.

Selected Papers

McClintock J, Carlson R, Mann D and Prince VE. 2001. Consequences of Hox gene duplication in the vertebrates: An investigation of the zebrafish hox paralogue group 1 genes. Development 128, 2471-2484. (PubMed)

Hunter MP and Prince VE. 2002. Zebrafish Hox paralogue group 2 genes function redundantly as selector genes to pattern the second pharyngeal arch. Developmental Biology 247, 367-389. (PubMed)

Prince VE and Pickett FB. 2002. Splitting pairs: Diverging fates of duplicated genes. Nature Reviews Genetics 3, 827-837. (PubMed)

Hurley I, Hale, M.and Prince VE. 2005. Duplication events and the evolution of segmental identity. Evolution and Development 7, 556-567. (PubMed)

Hurley IA, Mueller RL, Dunn, KA, Schmidt EJ, Friedman M, Ho RK, Prince VE, Yang Z, Thomas MG and Coates MI. 2007. A New Time-scale for Ray-Finned Fish Evolution. Proceedings of the Royal Society B: Biological Sciences 274, 489-498. (PubMed)

Hurley, IA, Scemama, J-L and Prince, VE. 2007. Consequences of hoxb1 duplication in teleost fish. Evol Dev. 2007 9, 540-54. (PubMed)

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