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Cover picture, Developmental Biology, September 15th 2007.

"Cell transplantation reveals cell-autonomous function of Prickle1b in zebrafish facial neuron migration. At gastrulation stage rhodamine labeled cells were transplanted from an islet-GFP transgenic embryo into the hindbrain primordium of a Prickle1b-deficient host. A composite confocal Z-stack is shown of a 36 hour host. All donor-derived cells are red, donor-derived branchiomotor neurons are also islet-GFP labeled (green). The location of all branchiomotor neurons is revealed by anti-islet1 antibody labeling (blue). The green donor-derived facial neurons have undergone normal migration, while blue Prickle1b-deficient neurons do not migrate. See Rohrschneider et al., 2007 (PubMed)."

 

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